Doublecortin Antikörper

Produktnummer ABIN2719680

Dieses Anti-Doublecortin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Doublecortin in WB, IF und FACS. Geeignet für Human.

Kurzübersicht für Doublecortin Antikörper (ABIN2719680)

Target: Doublecortin (DCX)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Doublecortin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 4A3

Produktdetails anti-Doublecortin Antikörper

Produktmerkmale: Homo sapiens doublecortin (DCX), transcript variant 2

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human DCX (NP_835365) produced in HEK293T cell.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:2000, IF 1:100, FLOW 1:100

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu Doublecortin

Target: Doublecortin (DCX)

Andere Bezeichnung: DCX

Hintergrund: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 40.4 kDa

Gen-ID: 1641

NCBI Accession: NM_178152

HGNC: 1641